IMPORTANT MESSAGE
Like many other companies and institutions around the world, we are experiencing interference with some of our systems within the TNT network.
We are implementing remediation steps as quickly as possible. We have implemented operational contingencies to continue to complete collections from customers with scheduled stops. For customers who do not have a regular stop, collection should be arranged via our customer service centers.
Customers may experience delays in the transit of shipments, particularly inter-continental or non-EU European delivery, as we work to remediate our systems. Additionally, if customers do not have the facility for self-labeling, they may also experience delays.
We are not able to collect shipments of dangerous goods at this time.
We regret any inconvenience to our customers.
Determination of Isotopic Purity by Accurate Mass LC/MS
Determination of Isotopic Purity by Accurate Mass LC/MS
Following the synthesis of isotopic labelled APIs at Almac, or stability testing, it is often necessary to accurately determine the isotopic enrichment of the compounds by mass spectrometry. This process is often complicated if the compound in question contains a variety of labelled atoms, including C, N and H, or where the isotopes resolution between the isotopes of labelled compounds and this has allowed more accurate extraction of these isotopes than ever before. With this high degree of mass accuracy, it is possible to accurately quantify the labelled composition of the compounds in question. A case study for the determination of isotopic purity of a compound manufactured at Almac which contained two C atoms and two N atoms is presented.
